Isothiazolinone are generally safe when used within regulated concentrations, but improper use may pose risks:
Safety under standard use: In cosmetics, the EU, China, and other regions strictly limit the maximum concentration of CMIT/MIT (≤0.0015%), and BIT (≤0.1%), which has low skin irritation and no obvious toxicity to the human body. In industrial water treatment, the dosage (5-20 ppm) will not cause harm to operators through normal contact (with protective measures).
Potential risks: High concentrations of isothiazolinone (e.g., CMIT/MIT raw liquid with a concentration of 10%-15%) may cause skin redness, itching, or allergic reactions (especially for sensitive skin groups). Long-term inhalation of high-concentration aerosols may irritate the respiratory tract. In addition, if it is not properly treated and discharged into the environment, it may have a certain impact on aquatic organisms (e.g., inhibiting the growth of algae in natural water bodies).
